This story of split personality, has Dr. Jekyll a kind and charitable man who believes that everyone has two sides, one good and one evil. Using a potion, his personalities are split, creating havoc.
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The Plot According To Wiki :
Henry Jekyll (John Barrymore) is a doctor of medicine, but he is also an "idealist,philanthropist." When he is not treating the poor in his free clinic, he is in his laboratory experimenting. Sir George Carew (Brandon Hurst), the father of his fiancée, Millicent (Martha Mansfield), is "piqued" by Dr. Jekyll. "No man could be as good as he looks," Carew says.
Following dinner one night, Carew taunts Dr. Jekyll in front of their friends, Edward Enfield (Cecil Clovelly), Dr. Lanyon (Charles Lane) and Utterson (J. Malcolm Dunn) proclaiming "In devoting yourself to others, Jekyll, aren't you neglecting the development of your own life?" "Isn't it by serving others that one develops oneself," Jekyll replies. "Which self? Man has two - as he has two hands. Because I use my right hand, should I never use my left? Your really strong man fears nothing. It is the weak one who is afraid of experience. A man cannot destroy the savage in him by denying its impulses. The only way to get rid of a temptation is to yield to it. With your youth, you should live - as I have lived. I have memories. What will you have at my age?"
And thus the seed is sown, and Jekyll begins his experiments. As he observes, "Wouldn't it be marvellous if the two natures in man could be separated - housed in different bodies? Think what it would mean to yield to every evil impulse, yet leave the soul untouched!" Finally, Jekyll develops a potion that turns him into a hideously evil creature that he calls Edward Hyde. As this creature, he is not recognizable as Dr. Jekyll, and, so, to facilitate the comings and goings of Hyde, he tells his servant, Poole (George Stevens), that Hyde is to have "full authority and liberty about the house."
Jekyll thus begins to live his double life. Hyde sets up a room in one of the seediest parts of London. He brings in a girl from the dance hall, Gina (Nita Naldi), to live with him there and frequents opium dens, dance halls, and bars - any place that satisfies his evil desires. Although Jekyll has developed a potion that will also return him to his original appearance and character as Dr. Jekyll, each time he takes the potion to become Edward Hyde, he worsens. He not only looks more evil, he becomes more evil, as well.
Millicent Carew is worried about the absence of her fiancé, so Sir George goes to call on Jekyll to see what is the matter. Although Jekyll is not home when he calls, Sir George encounters Hyde in the street just as he knocks a small boy to the ground injuring him. To make recompense for his actions, he goes and gets a check which he returns to the boy's father. Carew notices that the check has been signed by Dr. Jekyll. He confronts Poole who tells him the story of Edward Hyde.
In the meantime, Hyde/Jekyll has returned to the lab and, after drinking the potion, returns to his original self. Sir George finds him in the lab and demands to know his relationship with "a vile thing like Hyde?"
"What right have you to question me - you who first tempted me?" says Jekyll. Sir George angrily retorts that unless Jekyll is forthcoming with an explanation, he must object to his marriage to Millicent. This angers Jekyll to the point that he suddenly becomes Hyde, right in front of Sir George's eyes, without benefit of the potion. Sir George runs into the courtyard where Hyde catches him and clubs him to death with his walking stick. Hyde runs to his apartment and destroys any evidence that may link him to Jekyll. He eludes the police by only minutes and returns to his lab where he is able to drink the potion that restores him as Jekyll.
In the ensuing days, as Millicent grieves, Jekyll is tortured by his misdeeds. Soon, the drug needed to make the potion that will return him as Dr. Jekyll is depleted and cannot be found in all of London. Jekyll stays locked up in his lab fearing he may become Hyde at any moment. Millicent finally goes to see him, but just as she is about to enter the lab, he begins to transform into Hyde. Jekyll consumes the poison in the ring he took from the Italian dancer before he opens the door, fully transformed into Hyde. He lets her in, locks the door and grabs her in his arms. Suddenly, he starts convulsing. Millicent runs from the lab and when Lanyon comes in, he finds Hyde sitting in a chair, having just died, and his appearance returned to that of Dr. Jekyll. He discerns that Jekyll committed suicide, and calls the others (Poole, Utterson and Millicent) in, but declares to them that Hyde has killed Dr. Jekyll. In the final shot, Millicent is grieving next to the body of Dr. Jekyll.
Mining Dr. Jekyll And Mr.Hyde John Barrymore 1920 For Your Old School Horror Campaign
There is a metric ton here to mine. The silent era film makes a great jump off point for a Gaslight Cthlhu game. The loose ends of the film allow a DM to weave his players in and out of the action as the descent of Jekyll begins.
There are a few loose ends as the movie progresses. For example, He brings in a girl from the dance hall, Gina (Nita Naldi), to live with him there and frequents opium dens, dance halls, and bars - any place that satisfies his evil desires. There is the Italian dancing girl that Hyde has living with him. The implication that she might be pregnant is slightly staggering. Imagine the Jekyll and Hyde formula racing through a baby's body and the implications of a child growing up under its influence.
Then there's the laboratory of the good doctor at the end of the film. Does it hold the secret to this weirdly menacing formula? What sort of soul wrenching spiritual transformation might this do in the wrong hands.
There's also the clinic with its wide array of potential NPC's just waiting for someone to flesh these characters out. They're still going to need help no matter what. So what's the connection?
There was something weird and slightly sinister about the meetings that the various older gentlemen that had business with Jekyll. They seemed almost like a secret society and more on the higher end of the scale of weird conspiracy cults.
Then there's Hyde's apartment in the Soho section of London. What weird secrets does this place hold. Could a copy of the formula be hidden in some secret compartment or a hidden floor board along with a stash of drugs and supplies.
Then there's the little matter of that will of Jekyll's and his other hidden lairs throughout London. Could the other professionals that Jekyll knew even to the very end know more then they're telling? 
The megadungeons of the opium dens of London. The weird mazes of drug hazed strangeness where Hyde had his meetings with fellow sinners. Could Hyde have met up with cultists and other esoteric types and shared his secrets of "things men wasn't meant to know". It seems to me that this film could well be a jump off point for an entire campaign. This film might be the be legacy for a whole pack of horror trouble for your game. 
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